Efficiency of naringi crenulata (roxb.) nicolson and coix iacryma-jobi linn crude extracts for tyrosinase inhibition

Abstract

The objectives of this research were to study chemical composition of crude extract from Naringi crenulata (Roxb.) Nicolson and Coix lacryma-jobi Linn, to determine the appropriate ratio of crude extract between Naringi crenulata (Roxb.) Nicolson and Coix lacryma-jobi Linn, to develop a facial washing gel derived from crude extract from Naringi crenulata (Roxb.) Nicolson and Coix lacryma-jobi Linn. The results showed that the crude extracts from Naringi crenulata (Roxb.) Nicolson and Coix lacryma-jobi Linn had the total phenolic at 45.21 and 38.24 g/ml respectively. Whereas, the total tannin from Naringi crenulata (Roxb.) Nicolson and Coix lacryma-jobi Linn was 33.76 and 22.08 g/ml, respectively. The steroids-terpene, flavonoid and alkaloid were found in the crude extract of Naringi crenulata (Roxb.)Nicolson. The Steroids-terpene and flavonoid was found in crude extract of Coix lacryma-jobi Linn. IC50 of the tyrosinase inhibition was 0.28 mg/ml. The ratio of the crude extract could inhibition the enzyme tyrosinase was 1:1 with the IC500.18 mg/ml. The facial washing gel had red–brown colour with slightly smell from the extract with stable bubble. In addition the pH of the product was 6.7