Synthesis characterization and antibiotic drug elease study from geopolymer

Abstract

The aims of this study were developed geopolymer matrix for controlled release amoxicillin ,antibiotic drug, in the in vitro gastric and intestines (pH 1 and pH 6.8 temperature 37 ºC conditions). Three formulations of geopolymer tablets (GeAmSF5, GeAmSF7.5 and GeAmSF10) which different silica fume content were used in this study. Geopolymer tablets were measured compressive strength and characterized by using 3D laser microscope, Scanning electron microscope (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The amoxicillin release was analyzed by UV-VIS spectrophotometer. It was found that amoxicillin in geopolymer tablet was more resistance with various extraction solvents (ethanol, water 50 oC , pH 1 and 12 solutions) than amoxicillin commercial tablet in 2 hours. Moreover, the amoxicillin constantly release from geopolymer matrix after 3 hours in both in vitro gastric and intestines. However, amoxicillin was more release in gastric than intestines condition due to the strong acid leached aluminum ion causing damages geopolymer structure. Mathematical modeling of amoxicillin release from geopolymer matrix was fitted best with Higuchi model indicating diffusion of the drug out of matrix.